What is body detoxification? Recovery of the body after intoxication Conduct detoxification at home

Detoxification of the body at home This is what you can do to help yourself right now. And you need help, trust me.

Do not agree? Are you eating right and exercising?

Do you regularly undergo medical examinations? Well, all this, of course, is necessary and wonderful.

But what about those ways of influencing health that we have no control over? Ecology, for example.

Every day we consume a huge amount of toxins without even thinking about it.

It is enough for residents of large cities and megalopolises to take a breath and exhale so that a lot of foreign, hostile substances enter the body.

How to start getting rid of them today - read the new material from Life Reactor.

About the garbage in your body

In confirmation of the words written above, we present the dry figures of statistics.

Scientists have calculated that every year 2 kg of solid substances contained in the air enter the human body; 3.75 liters of pesticides sprayed on vegetables and fruits; 5 kg food toxic preservatives.

Note that we are not talking about some grams, but about full-fledged, tangible kilograms. Know yourself, live and grass.

But if you are reading our blog, then the role of an observer is not for you, so today we will tell you how to get rid of all these"charms" at home.

Let's start to understand sequentially and in order.

So, toxins are substances of animal, plant or bacterial origin, which are based on protein.

It doesn't sound like it's that scary. However, their excess in the body can cause significant, sometimes even irreparable harm to all systems of human life.

These foreign substances, constantly penetrating our bioenergetic defenses and easily penetrating the body, reduce the strength of the immune system.

They worsen the composition of the blood and its circulation, negatively affect the general well-being and often become the cause of extremely serious diseases.

A bleak picture, right? You can even hang your nose and lower your hands, but you shouldn't.

Nature foresaw our carelessness and endowed the human body with the ability to cleanse itself.

However, we still cannot do without our help - the degree of environmental pollution is too high, there are too many low-quality products around.

So how can you help your body? A course of detoxification at home is the simplest remedy, but before using it, you need to go through the preparatory stage and give up for a while from:

fast food
semi-finished products
sparkling water
Smoked
fried

The easiest way to detox is with drinks.

The list includes only basic pollutants of the body, the use of which should be abandoned at least for a week.

It is better to replace junk food with fruits, vegetables, natural juices and mineral water.

Tip: drink plenty of beetroot and carrot juice - that's the key to a healthy life.

Detoxification of the body at home in 10 days

So, you pulled yourself together and went on a diet. The first thing to pay attention to is bowel cleansing.

Many important processes take place in it, the results of which are reflected in the performance of the whole organism.

Keeping the intestines clean and tidy is a responsible and difficult task, but several time-tested and experienced remedies come to the rescue, the effectiveness of which is confirmed by clinical studies.

So, they will help you:

Activated carbon. The most powerful adsorbent on a natural basis, available at any pharmacy for ridiculous money. Take it at the rate of 1 tablet per 10 kg of weight.
Raw or steamed vegetables. They contain a large amount of fiber, necessary for the normal course of digestive processes.
Nuts. They saturate the body with nutrients, give strength and launch internal filters in the human body.
Dairy products, especially kefir. They create and maintain beneficial microflora in the intestines, and destroy pathogenic ones. Remove toxins and wastes.

Kefir and nuts will help cleanse the body

Stocked up on everything on the list but don't know where to start? Just follow our 10 day body cleansing program and you'll be fine.

Day one and two: in the early morning, immediately after waking up, drink a glass of clean water at room temperature on an empty stomach. If there is melt water - even better. You can add a teaspoon of honey and the juice of half a lemon to it. Minimize the diet: only freshly squeezed vegetable and fruit juices. In between, you can drink herbal teas.

Day three-eighth: every morning we start in the same way as described in the previous paragraph. For breakfast, lunch and dinner - steamed vegetables, germinated cereals, plant seeds, especially flax. Don't forget about juices and teas.

Day nine and ten: in the morning a glass of water with honey and lemon juice, during the day - fresh or steamed vegetables. We introduce baked potatoes, boiled fish, low-fat cottage cheese and kefir, as well as seafood into the diet.

During these 10 days, the body will have time to cleanse itself, internal filtration processes will restart, and metabolism will accelerate.

Due to the removal of toxins and toxins, the composition of the blood will improve, and after it the general well-being.

This program is an excellent tool for detoxification of the body at home after drinking.

It is often used in specialized clinics, and quite successfully.

Bath - here is another powerful weapon to combat intoxication of the body.

On steamed skin, many pores open through which harmful substances are excreted in gigantic quantities.

Bath show both before the start of the ten-day cleaning course, and after.

Dairy products will be useful

In both cases, its effectiveness is difficult to exaggerate, but you should be careful: heart problems and a bath are incompatible things.

Before going to the steam room, it is better to consult a doctor.

We consolidate success

Here you have done it! A grateful organism endows you with good health, high spirits, activity and increased efficiency.

Work colleagues envy your healthy appearance, sparkle in your eyes and natural skin tone.

When asked how to achieve the same success, you tell a story about the inhuman feat of life on water, vegetables and fruits. But what's next? How to consolidate success?

First of all - proper and balanced nutrition.

You can choose a diet at your discretion, but in general, to protect the body from harmful substances, it is enough to exclude food of animal origin, as well as food that has undergone heat treatment.

In one case, it will be simply dead and empty, that is, not containing useful nutrients, in the other - obviously harmful.

This is especially true for frying in oil, and no matter which one, the difference will not be significant.

Sport. Regular physical activity is a guarantee of health along with proper nutrition.

In addition, playing sports triggers internal cleansing processes. Many toxins are perfectly eliminated through sweat.

Drink. Water should be constantly at hand, and preferably non-carbonated and mineral.

Melt water is even better, since it does not contain any harmful compounds, and its benefits are significant.

Drink as often as possible, and not only when your throat is dry from thirst, as the vast majority do.

And, of course, the best way to fix the detoxification of the body is another cleansing.

Spend it two to three weeks after the previous course.

Before that, try to follow the regimen, do not be nervous and carefully monitor your diet.

If you have done well with the ten-day fruit and vegetable run, then you can try a two-week diet.

However, if you feel that you are physically lacking strength, it means that the body is not yet ready for such serious changes.

After all, any changes, including those for the better, are difficult and require a thoughtful approach.

Start small, listen to yourself and constantly improve.

Believe me, you will never trade the feeling of health and happiness that detoxification brings for anything else.

Tip: If strict diets don't work, try detoxifying your body with activated charcoal. An effective and simple method, especially for beginners. You will not need much effort, but the result will not leave you indifferent, that's for sure.

Most of the toxins are fat-soluble molecules. While water-soluble molecules are excreted from the body

One of the reasons for the serious impact of the environment on human health is exposure to a huge amount of toxic substances. Toxins affect people through the air they breathe, the food and water they eat, and through the skin. Huge amounts of money are spent on the treatment of diseases caused by exposure to toxic substances on the human body. Intoxication can provoke the development of diseases such as various types of cancer, syndromes characterized by chronic fatigue, muscle weakness, mental impairment, and many other conditions.

Environmental toxins include substances such as heavy metals, organic pesticides, medicines, industrial substances that our body must “neutralize” and remove. The most important biochemical process for processing toxins and removing them from the body is the process of biotransformation or detoxification. This process involves Phase 1 cytochrome P450 enzymes and Phase 2 conjugation enzymes. Optimal functioning of the detoxification system is highly dependent on the nutritional support of the body. Therefore, it is not surprising that nutrients that support the process of biotransformation also reduce the symptoms of many diseases and slow the development of conditions associated with exposure to toxins.

Impact of toxins on chronic degenerative diseases

A growing body of evidence points to an association between toxin exposure and the etiology of a number of chronic conditions such as chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), fibromyalgia (FM), and atherosclerosis. Most often, these conditions are accompanied by symptoms such as persistent fatigue, myalgia, arthralgia, and mental impairment. What's more, a study from the New York Academy of Science has shown that individual responses to toxins vary and are a major susceptibility factor to developing these conditions.

The link between exposure to toxins from the environment on the body and the development of syndromes of CFS, MCC and FM is increasingly evident. Even more impressive is the relationship between environmental exposure and the development of many chronic degenerative diseases (Table 1). For example, there has been renewed interest in the role of environmental factors in the development of Parkinson's disease in the elderly after studying twins. The study did not find strong evidence of the influence of genetics on the development of Parkinson's disease in patients who developed the disease after the age of 50.

It is known that exposure to organic substances with low molecular weight can provoke the development of symptoms of Parkinson's disease. Epidemiological studies have shown that exposure to pesticides, chemicals used in agriculture, consumption of well water, proximity of housing to industrial plants, long-term occupational intoxication with chemical elements such as manganese, copper or lead, especially in combination with iron, are also associated with the development of the disease. Parkinson. Although the exact mechanisms of action of these toxins are not known, the body's ability to eliminate them is a major factor in the development of the disease.

Table 1. Typical clinical symptoms and conditions associated with exposure to environmental toxins.

Anomaly of fetal development
Atherosclerosis
Severe mood swings
Crayfish
chronic fatigue syndrome
Chronic immunodeficiency
contact dermatitis
Fatigue
Infertility
fibromyalgia
Headache
History of hypersensitivity to exogens, odors, or medications
Arthralgia
Kidney dysfunction
Learning Disabilities
Amnesia
Mineral imbalance (particularly zinc and calcium)
Multiple chemical sensitivity
Pain and weakness in the muscles
Recurrent yeast infections refractory to treatment
Panic attacks
Parkinson's disease
Noise in ears
Unusual reactions to medications and supplements
Worsening of symptoms after the use of anesthetics or during pregnancy

Much research has focused on the risk of initiating and developing various forms of cancer due to long-term exposure to toxins. Cancer is the third leading cause of death in children, after trauma and domestic violence, and cancer-related deaths are on the rise. For example, childhood cancer deaths increased by 13% between 1973 and 1977, and the incidence of non-Hodgkin's lymphoma and brain cancer increased by 30% and 21%, respectively, during the same period. There is a strong relationship between these cancers and exposure to various toxins, including organochlorinated pesticides, which damage the DNA of chromosomes.

What are toxins, toxicants and toxic substances?

The word "toxin" itself does not imply a specific class of substances, but rather means something that can harm the body. In other words, A toxin or toxic substance is a chemical or mixture that can cause harm to the body or pose a health risk when exposed to the body. According to some definitions, the word "toxin" can only be applied to poisonous substances of animal and vegetable origin, so to avoid confusion, the Environmental Protection Organization (EPA) and other government agencies use the word "toxicant" to refer to toxins. Each toxic substance has a certain concentration or toxic dose, upon reaching which the toxic effect of the substance begins. However, most of the substances considered environmental toxicants are harmful even at low doses. The following is a brief list of the most common classes of toxicants.

Industrial chemicals and combustion products.

One of the broadest categories of toxicants, virtually everyone is exposed to some degree of exposure to halogenated hydrocarbons such as polychlorinated biphenyls (PCBs) during the day. Volatile organic toxicants fall into a broad category of toxins that includes halogenated hydrocarbons. These toxicants are particularly dangerous because of their ability to be airborne.

Pesticides.

More than 800 different chemicals belong to this class of toxicants. Many industrial chemicals are designed to be toxic to some living organisms and are sold as pesticides, insecticides, and herbicides. Although the manufacturers of these agents attempt to selectively target substances to certain types of organisms - hoping to reduce their toxic effect on the human body - complete specificity of action is practically impossible and most pesticides are toxic to humans to some extent.

Violators (disintegrators) of the endocrine system.

Common endocrine disruptors include phthalates in plastic, certain types of pesticides, synthetic steroids in meat, and dichloro-diphenyl-trichloroethane (DDT). Biologists have long noted the relationship between the presence of these chemicals in the environment and infertility or genital deformity in animals. It is important to note that not all estrogen-active substances are considered endocrine disruptors. For example, substances such as soy isoflavones and flaxseed lignans have health benefits and are associated with normalizing estrogen balance and are considered selective estrogen receptor modifiers (SERMs) rather than endocrine disruptors.

Toxic metals.

Toxic metals, including lead, mercury, cadmium, and arsenic, are ubiquitous in the environment and often have a delayed effect as they accumulate in the body. For example, lead can be sequestered in bone tissue, displacing calcium, and has a half-life of 62 years. The results of lead intoxication include DNA damage, immune system suppression, anemia, depression, hypertension, kidney disease, and increased caries.

preservatives and drugs.

The greatest toxic effect is what we consume through the mouth. Foods, medicines, and water containing toxic substances travel through the gastrointestinal tract to the intestines, where they can be absorbed. Medicines enter the body not only with those medicines that we purposefully consume. In fact, some drugs - including growth hormones and antimicrobials - are considered one of the main contaminants in food.

Concern about long-term exposure to low doses of toxins is increasing due to the large amount of epidemiological evidence that exposure to even low doses can be associated with the development of a variety of diseases and pathological conditions. It becomes obvious that it is impossible to consider the impact of individual toxins, since we are exposed to their complex effects. Moreover, the actions of toxins can complement each other if the toxic effects are carried out through the same pathways. Of even greater concern is the fact that many toxic substances are fat soluble and therefore can be deposited in tissues and remain there for many years. Thus, toxins can continue to accumulate in the body and affect tissues at higher concentrations than they are present in the environment.

How does the body remove toxins?

Most of the toxins are fat-soluble molecules. While water-soluble molecules are excreted from the body in the urine, fat-soluble molecules cannot pass directly into the urine, instead they are attracted to the lipids of cell membranes. This allows toxins to easily move into the cell where they can accumulate and have a toxic effect.

To remove these diverse toxins, the body has a comprehensive integrated system designed to convert fat-soluble toxins into water-soluble molecules, after which the converted toxins can be directly excreted through the renal tubules or gallbladder. This system is called the detoxification or biotransformation system and includes 2 steps: Phase 1 bioactivation and Phase 2 conjugation. During the initial phase of metabolism, biotransformation reactions occur to convert fat-soluble toxins into water-soluble molecules before entering the circulation system. Sometimes toxins are detoxified even before entering the liver by the same biotransformation reactions in the intestinal tract. About 25% of biotransformation processes in the body occur in the intestinal mucosa, which makes the mucosa the second most actively involved tissue in the detoxification process. All intestinal cells have the same ability to detoxify.

Phase 1 and 2 biotransformation reactions work in concert. Phase 2 of detoxification converts fat-soluble toxins into water-soluble molecules by attaching the toxin to another molecule that is water-soluble (i.e., a conjugation reaction). This looks like a simple one-step process, but it's complicated by the fact that most toxins don't have a reactive site that a water-soluble particle can easily attach to. Therefore, the toxin must form a reactive site for the attachment of a water-soluble particle. This is done through the action of Phase 1 enzymes.

Bioactivation Phase 1

Phase 1 reactions are catalyzed by many different enzymes; the largest number belongs to the family of cytochrome P450 enzymes (CYP450). The CYP450 enzymes have a broad specificity and use the reduced form of nicotinamine adenosine dinucleotide (NADH) as a cofactor in the conversion of oxygen to a hydroxyl group for fat soluble toxicants. The result of this reaction is the formation of a reactive site in the transformed toxicant. This reactive hydroxyl site is similar to the site on reactive oxygen species (ROS) and can easily attach to other molecules such as DNA and proteins. Sometimes products after passing through this stage of detoxification become water-soluble by attaching hydroxyl groups and can be excreted. This is the case, for example, with caffeine, which is only exposed to Phase 1 prior to excretion. However, not all toxins undergo this direct one-step excretion, and most activated toxicants or reactive intermediates require conjugation to larger, more water-soluble particles to effectively alter their lipid characteristics. Over 10 families of cytochrome P450 enzymes have been identified in humans. Each of these families has several subfamilies.

Many food ingredients support CYP450 responses, including niacin, which is required for the formation of NADH. In addition, activation reactions often also generate ROS as by-products. Dietary antioxidants may help protect tissues from ROS damage that can occur in this reaction.

Phase 2 conjugation

One result of Phase 1 activation is that a substance called a reactive intermediate often has more reactivity and potentially more toxicity than the parent molecule. Therefore, it is important that this molecule is converted to a non-toxic, water-soluble molecule as early as possible. Conjugation of reactive intermediates to water-soluble molecules is accomplished through Phase 2 conjugation reactions, which include glucuronidation, sulfation, glutathione conjugation, amino acid conjugation, methylation, and acetylation.

These reactions require not only water-soluble species to attach to toxicants—for example, sulfate during sulfation or glucuronic acid during glucuronization—but also a large amount of energy in the form of adenosine triphosphate (ATP). In addition to energy storage, Phase 2 reactions require a sufficient, constantly replenishing amount of cofactors, as these cofactors attach to toxins and are then eliminated. Certain nutrients and phytonutrients support Phase 2 reactions.

The role of energy production and oxidative stress in the realization of toxicity

As can be noted, the production of ATP is a necessary condition for adequate biotransformation. Producing enough ATP requires healthy mitochondria, which are supported by nutrients. Unfortunately, many toxicants can inhibit mitochondrial function, which can lead to a decrease in the biotransformation capacity of other toxins. For example, MPTP toxin inhibits respiratory chain complex I and mitochondrial DNA replication. The production of ROS is also a result of energy production, and excessive levels of these harmful molecules are called oxidative stress and are associated with intoxication. Nutrients that support mitochondrial function include essential energy cofactors: thiamine, riboflavin, niacin, pantothenic acid, and magnesium. In addition, nutrients that help in protecting the body from oxidative stress are useful, such as vitamins C and E, zinc, selenium, and copper.

Digestion and excretion during intoxication

The normal process of digestion can have a critical impact on detoxification. Food intake is known to affect the absorption of chemicals through gastric emptying, intestinal transit, pH, and bile production. Since medications are examples of how toxins enter the body, it is reasonable to assume that toxins are affected in the same way. In particular, toxins and drugs that are conjugated in the intestinal tract during the first stage of metabolism are excreted primarily through the bile, and are therefore excreted in the feces. For their complete removal, regular bowel movements are necessary. Dietary fiber contributes to normal excretion, which is important for the elimination of biotransformed toxins. It binds certain toxins, thereby providing a pathway for their removal when ingested. In addition, sufficient water intake is necessary to maintain normal kidney function and to facilitate the excretion of toxins from the urinary circulatory system.

In addition to supporting excretion, nutrients support biotransformation in many other ways. Adequate blood glucose levels are necessary to maintain the production of glucuronidation factor. Interestingly, diabetes is one of the diseases associated with impaired Phase 1 activity.

Support for energy production and the formation of new enzymes (protein synthesis) are also important for the detoxification process. Therefore, an adequate intake of carbohydrates, energy-supporting fats, and high-quality proteins is necessary to maintain defense mechanisms against toxic damage. Fats can be a problem, as many people consume excess amounts of unhealthy fats. Moreover, when exposed to toxins, sufficient absorption of nutrients (including fats) does not occur in the intestinal tract due to impaired intestinal permeability. Therefore, a highly bioavailable fat source that directly supports energy production is beneficial. Medium chain triglycerides (MCTs) are fatty acids that fit this profile. Interestingly, olive oil, in contrast to sunflower, corn, or fish oils, appears to be protective against chemically induced liver fibrosis in rats, and thus may be a good source of fat in a detox program.

Balance and normal detoxification

Depletion or lack of any cofactors necessary for the detoxification process is a serious prerequisite for the development of intoxication. In Phase 1, the toxin is prepared for conjugation in Phase 2, in which a water-soluble group is attached to the toxin, making it non-toxic and facilitating its excretion. These two phases must work in harmony and balance. In particular, Phase 2 processes must proceed at the same rate as the formation of reactive intermediates in Phase 1, otherwise there will be an imbalance in the production of reactive substances. If a reactive intermediate is generated in Phase 1 that is not immediately conjugated and cleared, it can act like ROS and attach to DNA, proteins, and RNA, causing irreversible cell damage.

There are many Phase 2 processes that need to be maintained in order to achieve a balanced, normal, and complete detox. Many phytonutrients that have protective properties against toxin damage can induce the expression of genes that regulate the synthesis of Phase 2 enzymes that promote the production of conjugative enzymes and lead to an increase in Phase 2 activity. Phytonutrients useful for inducing Phase 2 activity include: ellagic acid (found in pomegranate and many berries), catechins from green tea and grapes, glucosinolates from cruciferous vegetables such as watercress and broccoli.

As mentioned earlier, Phase 1 bioactivation is required to form an active site for the addition of a water soluble group. However, Phase 1 bioactivation "activates" the toxin to a more reactive substance. A double-edged sword means that some activity is needed, however excessive activity can lead to the formation of reactive intermediates, producing too many of them and therefore reducing the body's ability to neutralize these reactive substances into non-toxic molecules ready for excretion in Phase 2.

Some phytonutrients help maintain Phase 1 activity, such as indole-3-carbinol from broccoli, which provides some support for CYP1A enzymes. However, over-activation of Phase 1 is of concern as it is associated with persistently high levels of toxins that effectively induce Phase 1 activity. more than the moderate support provided by indole-3-carbinol.

Bifunctional Detox Support: Achieving Balance

As the name implies, substances that provide bifunctional support for the detoxification process maintain the optimal activity of the enzyme systems of both Phases. The normal activity of Phase 2 is associated with the induction of these enzymes, i.e. provides higher activity and the formation of appropriate cofactors.
Since there are many Phase 2 enzymes, an effective bifunctional modulator will increase the activity of several enzymes at the same time. Bifunctional modulators include: ellagic acid, catechins, and glucosinolates, some of which will be described in more detail.

Maintaining normal Phase 1 activity requires maintaining a balanced level of Phase 1 enzymes. Bifunctional modulators are often able to inhibit Phase 1 enzymes, if present in high amounts, without completely inhibiting their production. For example, while ellagic acid may inhibit CYP1A induction when exposed to a mutagenic benzo(a)pyrene, possibly through direct coupling to the mutagen, it does not inhibit beneficial and desirable CYP1A activity.

Many bifunctional modulators also contribute to optimal balance through their ability to act as antioxidants and to bond with reactive intermediates and side ROS in Phase 1 reactions. Therefore, bifunctional modulators help maintain optimal detoxification balance by modulating Phase 1 processes, inducing some of the Phase 2 processes and minimizing damage by reactive intermediates.

These properties of bifunctional modulators are one of the reasons for the relationship between a diet high in vegetables and fruits and a reduced susceptibility to the development of diseases such as cancer, since vegetables and fruits are a source of many bifunctional modulators.

Table 2. Clinical preconditions for biotransformation maintenance programs

Reduced overall toxic load and exposure to toxicants
Providing complete balanced support for biotransformation and conjugation reactions
Support for healthy digestion and excretion
Providing support for energy production during a detox program
Maintenance of endogenous antioxidant mechanisms of biotransformation and detoxification of heavy metals
Providing methyl group donors to maintain methylation pathways

Water fasting and detox

Water fasting can impair the body's ability to maintain detoxification. Fasting and alcohol consumption over-induce the CYP450E family of enzymes, resulting in an imbalance in detoxification. in addition, fasting leads to the predominance of muscle catabolism over fat, which is extremely unhealthy. Fasting also leads to a decrease in the consumption of essential cofactors, which provokes a decrease in sulfation, a decrease in glutathione levels and a decrease in the amount of conjugation cofactors required for glucuronidation. Animal studies have shown that fasting on water leads to a decrease in glutathione levels and an increase in the likelihood of developing intoxication when exposed to toxins. Therefore, Phase 2 reactions slow down and reactive intermediates accumulate in the body.

Nutritional Support for Biotransformation

Providing the body with macronutrients is very important for a detox program. Fasting has many side effects on the body, including reduced energy production, catabolism of lean tissue, over-induction of certain Phase 1 processes with an associated increase in oxidative stress, and decreased levels of Phase 2 cofactors. The detoxification process requires energy and is a metabolic burden on the body. Instead of reducing nutritional support, the body needs an efficient source of nutrients. However, this nutrient source must have a low allergenic potential in order to reduce the body's inflammatory burden and levels of potentially allergenic toxins. In general, to maintain a normal metabolism during the detox period, an important nutritional basis in the form of proteins, carbohydrates and fats.

The benefits of fiber

Fiber can be beneficial to the detox process for a variety of reasons. Fiber supports the cellular barriers of the intestinal mucosa and contributes to the maintenance of colon health, which leads to a reduction in the toxic load and the implementation of the first line of protection of the system. Fiber promotes the excretion of conjugated toxins in the bile and may reduce the absorption of some toxins. Importantly, fiber directly attaches to toxins, thereby removing them before they interact with the body and cause damage at any level. Fiber from rice bran attaches predominantly to mutogens, unlike fiber from wheat, corn, barley, and oats.

High quality proteins

In addition to nutrients and fiber, Phase 2 conjugation requires high quality proteins that provide the body with methionine and cysteine in a highly absorbable form, as these amino acids can be used to form sulfation cofactors and synthesis of glutathione. High-quality proteins may also be helpful in mercury intoxication, as exposure to mercury depletes specific amino acids that are precursors to neurotransmitters. Methionine is also a component of S-adenosylmethionine (SAM) and is required for methylation.

Sulfation Support with N-Acetylcysteine (NAC) and Sodium Sulfate

Sulfate group donors such as NAC and sodium sulfate are essential to a detox program. Oral NACs increase levels of glutathione, which is activated in the body. Glutathione is not only a glutathione conjugation cofactor, but is also the main pathway for heavy metal detoxification due to the ability of metals to attach to the sulfur of glutathione. Due to the use of glutathione in the synthesis, cysteine - the main factor in overcoming metal toxicity - is depleted in case of accumulation of toxic metals in the body. To support sulfation cofactor status and glutathione production, replenishment of sulfation cofactors by taking cysteine (in the form of NAC) at a dosage of 200 to 500 mg per day is recommended.

Methylation Support with Vitamin B12, Folic Acid, Methionine and Choline

The methyl donors choline, methionine, and folate are called “mobile methyls” because they are used in metabolism and therefore must be replenished. Interestingly, dietary deficiency of mobile methyls is the only nutrient deficiency that is itself carcinogenic. Dietary deficiency of free methyls can also induce the activity of CYP1A enzymes in animal studies. Part of the role of dietary labile methyls in maintaining health is to maintain detoxification balance by providing cofactors for the Phase 2 conjugation reactions. Vitamin B12 and folic acid ensure normal homocysteine metabolism, which allows SAM remethylation. The biologically active natural form of folate is 5-methyltetrahydrofolate.

Replenishment of choline reserves is extremely important. Since choline can be synthesized endogenously from methionine, it has been concluded that dietary sources are not required to replenish it. However, a lot of experimental evidence has called this into question and has shown that dietary sources of choline are necessary. For example, choline deficiency leads to fatty liver disease and other liver diseases. Not so long ago, the Committee on Nutrition and Medicine of the National Academy of Sciences classified choline as an essential nutrient.

Ellagic acid from pomegranate

In experiments with animals, ellagic acid contributed to a significant reduction in the incidence of tumor development in chemically induced oncogenesis of the lungs and liver, protection from carbon tetrachloride liver damage, improved production of glutathione, and a decrease in lipid peroxidation. Ellagic acid can also directly neutralize the toxicity of some metals (such as nickel) through their chelation and promote their elimination, thereby protecting the liver from additional damage and oxidative stress.

Ellagic acid is a bifunctional modulator and contributes to maintaining the balance of detoxification through several mechanisms: 1) induces the production of glutathione-S-transferase and other Phase 2 processes at the gene level, 2) modulates the activity of CYP1A enzymes (reduces their activity in case of excessive synthesis), 3) directly attaches to some toxic substances (for example, benzopyrene) of the environment, making them non-toxic and facilitating their excretion. Ellagic acid can directly act on DNA, protecting it from carcinogenic mutations.

Green tea catechins

There are many publications regarding the health benefits of catechins. Evidence suggests that catechins (a class of flavonoids abundant in green tea extract) are bifunctional modulators that positively influence Phase 2 detoxification by inducing glucuronidation reactions and glutathione conjugation. Animal studies have shown that green tea catechins have antitumor and antimutagenic potential. These substances are powerful antioxidants and bind directly to many toxic substances.

Epidemiological evidence suggests that catechins may protect a person from many types of cancer, although other data suggest that consumption of beverages containing catechins, such as tea, is inversely related to the incidence of Parkinson's disease. This prompted scientists from the National Cancer Institute to explore the potential of green tea extract containing catechins as a chemotherapeutic agent.

Interestingly, catechins induce some of the Phase 1 processes; however, newer evidence suggests that catechins also selectively inhibit some Phase 1 processes. toxins. This ability to modify Phase 1 levels, causing moderate induction and inhibition of over-induction, is associated with some of the properties of catechins. In addition, this study showed that a full spectrum of catechins is required for this effect and that different catechin molecules act as differentiated antagonist and agonist of CYP450.

The powerful antioxidant activity of catechins also allows them to attach to reactive intermediates that are formed in Phase 1 and are not immediately conjugated in Phase 2 reactions. This is another reason why this class of flavonoids can help support detoxification balance. One cup of tea contains 100 to 200 mg of catechins, which account for at least 90% of the beneficial effects of green tea. Green tea catechins also contribute to the maintenance of beneficial intestinal microflora, pH and normal bowel function - 3 aspects that are important for the initial stage of optimal detoxification.

watercress glucosinolates

Watercress (Nasturtium officinale), like other cruciferous vegetables such as broccoli, is high in glucosinolates. Glucosinolates are precursors to several bioactive isothiocyanates, including phenylethyl isothiocyanate (FITC). Studies have shown that in the human body, glucosinolates can be efficiently converted to FITC by the intestinal flora after consumption of watercress.

Watercress also contains very high doses of FITC. FITC from watercress is able to inhibit chemically induced carcinogenesis in the lung and colon in rats and promote the excretion of carcinogens in humans. A positive mechanism for this action involves selective inhibition of Phase 1 processes with a corresponding induction of glucuronosyl transferase and glutathione S-transferase in Phase 2. As epidemiological data show, the biochemical activity of watercress isothiocyanates is considered one of the reasons cruciferous plants have protective properties.

Silymarin from milk thistle

Several recent reviews have discussed the traditional use of silymarin as a hepatoprotector, while recent studies have reflected more specific functions of silymarin in the area of liver protection. For example, silymarin at a dosage of 400 mg per day improves liver function in patients with various etiologies of diseases, including toxic hepatitis as a result of exposure to industrial phenols, such as toluene. Silymarin also increases blood levels of glutathione and glutathione peroxidase in patients with liver disease and induces glutathione peroxidase activity in animals. Silymarin glycosides have powerful antioxidant effects, so silymarin can act as a bifunctional modulator.

Artichoke

Traditional medicine has long used artichoke extract (Cynara scolymus) as a liver protectant. Several other bioactives have also been identified, including chlorogenic acid, cynarin, caffeic acid, and luteolin. Consumption of artichoke extract capsules increases the absorption of these bioactive substances in the human body, leading to the production of beneficial metabolites such as ferulic acid. Ferulic acid, chlorogenic acid, and cynarin provide powerful antioxidant protection, reflecting the health benefits of these substances. Moreover, in a liver cell culture study, artichoke extract not only provided antioxidant protection against toxic chemically induced stroke, but also reduced the loss of cellular glutathione reserves.

Results

Optimizing the body's ability to process and excrete toxins is essential to maintaining optimal health.

Airborne toxins are especially dangerous, as they enter the body through the sinuses and can cross the blood-brain barrier. They can "travel" along the olfactory nerve directly to the brain. However, reducing toxic exposure is only part of a successful strategy to reduce susceptibility to the development of intoxication-related disorders. Low allergenic targeted nutrition with a full spectrum of cofactor precursors, excretion support, and bifunctional modulators to achieve a balance of Phase 1 and Phase 2 biotransformation promote balanced detoxification and support optimal health throughout life.published

Detoxification of the body - how to do it yourself? is a term often used by healthcare professionals. In a narrow sense, it means a vital function of cells, the missing functionality of which can lead to morbidity and mortality.

Purification process

The process of detoxification involves the mobilization, biotransformation, neutralization and elimination of toxins from the body.

Digestive disorders, hypersensitivity, respiratory symptoms, skin problems with chronic fatigue syndrome, without pathophysiological changes and diagnosis can be a sign that the body needs detoxification.

In addition to poor nutrition, we are exposed to environmental xenobiotics. Many xenobiotics can cause physiological and pharmacological reactions: homeostasis, proliferation, apoptosis and necrosis. The uncontrolled effects of xenobiotics without an adequate detoxification process can lead to adverse health effects.

There are three main entry points for xenobiotics into our physiological system: the digestive and respiratory systems and the skin. The skin is our largest organ, which is often exposed to xenobiotics. However, the liver is a key organ that is involved in detoxifying the body. The liver cells both filter and neutralize the high concentration of xenobiotics, bacteria and other toxins from the blood.

A very important function of the liver is the production of bile, which is necessary for the absorption and excretion of the digestion of fats. Just excessive consumption of alcohol, acetaminophen and other drugs and chemicals, poor quality foods can cause liver damage.

Phytotherapy

nutritional supplements and herbal detoxifiers.

The body should be maintained through the use of herbal teas and diuretics and other substances that have a beneficial effect on the body.

Milk thistle extract contains 80% of the active ingredient silymarin, a chemical compound that induces detoxification.

Milk thistle - has a positive effect on liver function, since, which has a regenerating and anti-inflammatory property, increases the secretion of bile, therefore improves digestion.

In the form of meal, milk thistle has a powerful cleansing effect. Removes even heavy metals. Cures cirrhosis and hepatitis. It is the meal of this plant that is the best means of restoring the liver of all known

Glucosinolates and isothiocyanates from broccoli.

Broccoli is a rich source of glucosinolates, glucoraphanin and isothiocyanate, which are strong detox inducers, stimulate antioxidant defenses and thus effectively protect against cancer.

Polyphenols from green tea.

Green tea polyphenols, with known antioxidant activity, have a powerful effect on detoxification. In one study, epigallocatechin gallate, a polyphenol from green tea, was shown to increase the activity of the enzyme glutathione S-transferase by 30 times.

Ellagic acid.

Ellagic acid is found naturally in various types of fruits (especially berries, raspberries, blackberries, strawberries, cranberries) and nuts and pecans. It is a stable flavonoid that works anti-mutagenic and anti-cancer. Ellagic acid increases the activity of the enzyme glutathione-S-peroxidase and phase II quinone reductase. Acai berries are a powerful antioxidant source, containing ellagic acid, multivitamins, amino acids, antioxidants and phytosterols.

Artichoke extract.

Artichoke protects liver cells, increases bile production, and also lowers cholesterol levels and has antioxidant properties.

Nutrition

With the beginning of cleansing, the body begins to get rid of accumulated toxins, which in the first days is accompanied by malaise. There are headaches, muscle and joint pains, chills and fever, diarrhea or constipation, irritability, depression, weight loss, fatigue, decreased vitality and sexual potential, feeling cold, sweating, etc. These are normal processes associated with the release of toxins from the body.

During this period, it is better to avoid the consumption of foods that cause hypersensitivity, allergic reactions and bowel problems. A milder cleanse can be done to help you manage your weight and improve your overall health. It is advisable to allocate a few free days for cleansing the body.

Quitting alcohol, smoking, and coffee will greatly help ease the detox process.

The first thing to do is eliminate toxic foods from your diet. Certain foods are known to clog the body.

These include fast food, artificial sweeteners, fried foods, and fatty foods.
You will also have to give up white sugar and salt.
Instead of coffee, try drinking herbal infusions.
Drink green tea as it contains polyphenols, which remove toxic substances from the body.
You can make a cleansing drink: add a little honey and lemon juice to a glass of warm water.
Diuretic and cleansing herbs - nettle, horsetail, sage, St. John's wort, mint, burdock, dandelion.
Eat plenty of fruits and vegetables, which also help cleanse the body.
You can eat all vegetables, except for carrots, beets, peppers, tomatoes, turnips, potatoes.
Load up on green veggies and leafy greens, which contain chlorophyll, which aids in the detoxification process. In addition, greens are rich in vitamins, minerals and nutrients.

In addition to fresh, organic foods, also include lemon in your diet (lemon juice mixed with warm water 2-3 times a day is excellent cleanser), olive oil, coconut oil, and apple cider vinegar, which will also help the body get rid of waste and toxins.

Detoxing the body at home is something you can help yourself with right now. And you need help, trust me. Do not agree? Are you eating right and exercising? Do you regularly undergo medical examinations? Well, all this, of course, is necessary and wonderful. But what about those ways of influencing health that we have no control over? Ecology, for example. Every day we consume a huge amount of toxins without even thinking about it. It is enough for residents of large cities and megalopolises to take a breath and exhale so that a lot of foreign, hostile substances enter the body. How to start getting rid of them today - read in the new material.

About the garbage in your body

In confirmation of the words written above, we present the dry figures of statistics. Prepare to be a little dizzy as scientists estimate that 2kg of harmful airborne solids enter the body of an adult every year; 3.75 liters of pesticides, which are generously sprinkled on vegetables and fruits, wherever you buy them; 5 kg of food additives and toxic artificial preservatives. Note that we are not talking about some grams, but about full-fledged, tangible kilograms. Know yourself, live and grass. But if you are reading our blog, then the role of an observer is not for you, so today we will tell you how to get rid of all these “charms” at home.

Let's start to understand sequentially and in order. So, toxins are substances of animal, plant or bacterial origin, which are based on protein. It doesn't sound like it's that scary. However, their excess in the body can cause significant, sometimes even irreparable harm to all systems of human life. These foreign substances, constantly penetrating our bioenergetic defenses and easily penetrating into the body, reduce the strength of the immune system, worsen the composition of the blood and its circulation, negatively affect the general well-being and often become the cause of extremely serious diseases.

A bleak picture, right? You can even hang your nose and lower your hands, but you shouldn't. Nature foresaw our carelessness and endowed the human body with the ability to cleanse itself. However, we still cannot do without our help - the degree of environmental pollution is too high, there are too many low-quality products around.

So how can you help your body? A course of detoxification at home is the simplest remedy, but before using it, you need to go through the preparatory stage and give up for a while from:

fast food
semi-finished products
sparkling water
Smoked
fried

The list includes only basic pollutants of the body, the use of which should be abandoned at least for a week. It is better to replace junk food with fruits, vegetables, natural juices and mineral water.

Tip: drink plenty of beetroot and carrot juice - that's the key to a healthy life.

Detoxification of the body at home in 10 days

So, you pulled yourself together and went on a diet. The first thing to pay attention to is bowel cleansing. Many important processes take place in it, the results of which are reflected in the performance of the whole organism. Keeping the intestines clean and tidy is a responsible and difficult task, but several time-tested and experienced remedies come to the rescue, the effectiveness of which is confirmed by clinical studies.

So, they will help you:

Activated carbon. The most powerful adsorbent on a natural basis, available at any pharmacy for ridiculous money. Take it at the rate of 1 tablet per 10 kg of weight
Raw or steamed vegetables. They contain a large amount of fiber necessary for the normal course of digestive processes.
Nuts. Saturate the body with nutrients, give strength and launch internal filters in the human body
Dairy products, especially kefir. They create and maintain beneficial microflora in the intestines, and destroy pathogenic ones. Remove toxins and waste

Kefir and nuts will help cleanse the body

Stocked up on everything on the list but don't know where to start? Just follow our 10 day body cleansing program and you'll be fine.

Day one and two: in the early morning, immediately after waking up, drink a glass of clean water at room temperature on an empty stomach. If there is melt water - even better. You can add a teaspoon of honey and the juice of half a lemon to it. Minimize the diet: only freshly squeezed vegetable and fruit juices. In between you can drink herbal teas

Day three-eighth: every morning we start in the same way as described in the previous paragraph. For breakfast, lunch and dinner - steamed vegetables, germinated cereals, plant seeds, especially flax. Don't Forget Juices and Teas

Day nine and ten: in the morning a glass of water with honey and lemon juice, during the day - fresh or steamed vegetables. We introduce baked potatoes, boiled fish, low-fat cottage cheese and kefir, as well as seafood into the diet

During these 10 days, the body will have time to cleanse itself, internal filtration processes will restart, and metabolism will accelerate. Due to the removal of toxins and toxins, the composition of the blood will improve, and after it the general well-being. This program is an excellent tool for detoxifying the body at home after drinking. It is often used in specialized clinics, and quite successfully.

Bath - here is another powerful weapon to combat intoxication of the body. On steamed skin, many pores open through which harmful substances are excreted in gigantic quantities. Bath show both before the start of the ten-day cleaning course, and after. In both cases, its effectiveness is difficult to exaggerate, but you should be careful: heart problems and a bath are incompatible things. Before going to the steam room, it is better to consult a doctor.

We consolidate success

Here you have done it! A grateful organism endows you with good health, high spirits, activity and increased efficiency. Work colleagues envy your healthy appearance, sparkle in your eyes and natural skin tone. When asked how to achieve the same success, you tell a story about the inhuman feat of life on water, vegetables and fruits. But what's next? How to consolidate success?

First of all - proper and balanced nutrition. You can choose a diet at your own discretion, but in general, to protect the body from a bunch of harmful substances, it is enough to exclude food of animal origin, as well as food that has undergone heat treatment. In one case, it will be simply dead and empty, that is, not containing useful nutrients, in the other - obviously harmful. This is especially true for frying in oil, and no matter which one, the difference will not be significant.

Sport. Regular physical activity is a guarantee of health along with proper nutrition. In addition, playing sports triggers internal cleansing processes. Many toxins are perfectly eliminated through sweat.

Drink. Water should be constantly at hand, and preferably non-carbonated and mineral. Melt water is even better, since it does not contain any harmful compounds, and its benefits are significant. Drink as often as possible, and not only when your throat is dry from thirst, as the vast majority do.

And, of course, the best way to fix the detoxification of the body is another cleansing. Spend it two to three weeks after the previous course. Before that, try to follow the regimen, do not be nervous and carefully monitor your diet. If you have done well with the ten-day fruit and vegetable run, then you can try a two-week diet. However, if you feel that you are physically lacking strength, it means that the body is not yet ready for such serious changes. After all, any changes, including those for the better, are difficult and require a thoughtful approach. Start small, listen to yourself and constantly improve. Believe me, you will never trade the feeling of health and happiness that detoxification brings for anything else.

Tip: If strict diets don't work, try detoxifying your body with activated charcoal. An effective and simple method, especially for beginners. You will not need much effort, but the result will not leave you indifferent, that's for sure.

Together with food, drinks (in particular, alcohol) and inhaled air, substances that contain toxins can enter the human body. Their accumulation has a negative impact on health. Thanks to the activity of internal organs and systems (kidneys, liver), natural detoxification and elimination of toxic substances, as well as their metabolites (decay products), occur.

When, under the influence of various factors, the natural mechanisms of self-purification fail, means are used to detoxify the body.

The cleaning method is selected taking into account the conditions that led to the deterioration of health:

Poisoning by harmful substances taken orally requires immediate gastric lavage until its contents are completely cleared. Local methods also include a cleansing enema, which helps to remove feces from the intestines, preventing the absorption of harmful compounds.

For these purposes, weak solutions are used that can be prepared at home:

potassium permanganate ("potassium permanganate");
baking soda;
table salt.

The second stage is absorption. The method is effective not only for oral use of toxic products, but also for inhalation of vapors and smoke. The names of the most common enterosorbents that are sold in any pharmacy and sold without a prescription:

Activated carbon;
Enterosgel;
Polysorb;
Smecta;
Polyphepan and others.

These drugs prevent further absorption of harmful components through the digestive tract, reducing the toxic effects on the body.

The next stage is the neutralization of potent compounds and their decay products. With alcohol, drugs, and other types of chemical intoxication, antidotes are used.

Special agents neutralize the action of histamine, the release of which leads to the development of most of the known allergic reactions (skin itching, hyperemia, swelling, etc.). For example, antihistamine complexes neutralize allergens that get inside from the outside or are formed as a result of autoimmune reactions. After taking desensitizing drugs, a fasting diet is recommended to relieve the increased load on the liver.

Detoxification after past infections is one way to restore a weakened immune system. Viruses, pathogenic bacteria and other pathogenic microorganisms, releasing waste products, slagging the body, worsening a person's well-being. Most modern antiviral drugs and antibiotics act not only on the main source of the disease, but also neutralize the effects of toxins.

Types of detox products

All drugs for detoxification of the body are divided into groups depending on the method of application, the mechanism of therapeutic action. There are medications:

selective action - an antidote that affects a certain type of substance (for example, the antidote of THC is sodium thiosulfate);
wide spectrum;
used orally (inside), injection, infusion (intravenous injection into the bloodstream);
to activate the physiological mechanisms of self-purification (emetics, laxatives, saluretics, diuretics, others);
for artificial detoxification (sorbents, pharmacological antagonists, plasma and blood substitutes).

The detoxification process involves the use of hardware methods of blood purification:

hemosorption, lymphosorption - removal from the blood and lymph of toxic products, their metabolites, carried out outside the body;
hemodialysis - extrarenal filtration with restoration of water and electrolyte balance;
laser blood irradiation (ILBI) - a modern method of photobiological effects, improves the functioning of erythrocytes, platelets, leukocytes;
plasmapheresis - an extracorporeal physiotherapeutic procedure, including blood sampling, its purification and return to the bloodstream;
hemotransfusion - blood transfusion.

Despite the high efficiency of these methods, they have a number of contraindications. To avoid serious complications and not harm your health, you should conduct a preliminary medical examination.

injection methods

Severe forms of poisoning are treated with drip intravenous administration of drugs under strict medical supervision. For intravenous injections, solutions are used:

Hemodeza;
Neocompensana;
Reamberina;
Reopoliglyukina and others.

In addition to providing a detox effect, these solutions normalize blood counts, improving its circulation, and have an antihypoxic effect, helping to accelerate oxygen metabolism.

Complementary Therapy

During the period of the main treatment, as well as after its completion, experts recommend taking balanced vitamin and mineral complexes. Replenishment of reserves of nutrients allows you to:

qualitatively improve the activity of internal systems (stabilize the hormonal background, enzyme activity, metabolism);
activate the protective functions of the body;
normalize well-being and psycho-emotional state.

The latter aspect is especially important for comfortable withdrawal from hard drinking, recovery from drug addiction.

Most useful during the rehabilitation period:

vitamin C - restores immunity, tones, normalizes the work of the cardiovascular system;
B vitamins - have a positive effect on the work of the central nervous system, the endocrine system;
potassium, sodium, calcium - are necessary for the full functioning of internal organs, are destroyed in large quantities during alcoholism, drug addiction;
magnesium - useful for the nervous system.

To eliminate problems with the emotional background, sedatives are prescribed that have a calming, relaxing effect. Their intake is especially important for preventing the development of an abstinence syndrome (cancellation) after stopping the use of alcoholic beverages or drugs.

The main share of toxins is deposited in the liver. To protect its cells from destructive influence, you should take a course of taking hepatoprotectors. They prevent the development of cirrhosis, promote tissue regeneration and restoration of organ functions.

At home, you should follow a diet. From the diet should be excluded:

fried, marinated, smoked dishes;
alcoholic drinks;
strong tea, coffee.

It is advisable to limit the intake of salt and sugar. Be sure to enrich the diet with fresh vegetables, fruits, herbs. For the speedy removal of toxins, it is important to observe the drinking regimen. An adult needs to drink at least 2 - 2.5 liters of clean water daily.

Detoxification of the body is a cleansing procedure that allows you to restore the normal functioning of all organs and systems. In mild forms of poisoning, it can be carried out at home. In acute, severe intoxication, immediate medical attention is required.